This Essential Knowledge Briefing explains how microfluidic cell culture devices and various high-resolution, live-cell imaging modalities have co-evolved to create microscale systems that give researchers exquisite control of the cell microenvironment. The goal of these systems is to create more in vivo-like conditions for cell-based assays while observing cell changes in real time. The reader will also learn about commercially available all-in-one microfluidic systems that allow investigators with little technical expertise to rapidly set up and conduct live-cell experiments to study cell behavior, responses, and interactions.
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