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Expert Insights

Exploring the Benefits of Targeted Protein Degradation with PROTAC® Degraders

Wiley Current Protocols
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For cells to maintain protein homeostasis, they make use of two pathways − the ubiquitin-proteasome system (UPS) and autophagy-lysosomal degradation. In the UPS, proteins are initially ‘tagged’ by multimers of the ubiquitin protein, followed by their breakdown by a large enzyme complex known as the proteasome. Autophagy sequesters proteins in double-membrane vesicles and delivers them to the lysosome for breakdown. New chemical biology tools are allowing the manipulation of these two cellular processes with the concept of targeted protein degradation (TPD). The advantages of TPD have resulted in a considerable degree of interest in both the pharmaceutical industry and academia due to its potential drug discovery capabilities.

This expert insight hopes to provide more information on TPD to traditional ELISA analysts, western blot users, life science researchers, and scientists across biopharmaceutical industries and academia, enabling you to further your studies in this field.

What you will learn about:

  • Design considerations for PROTAC® development
  • How fully automated westerns enable cutting-edge TPD research
  • Validating targets for TPD using dTAG – a comprehensive workflow solution
  • Automated profiling of PROTAC®-induced cereblon neosubstrate degradation using Simple Western™

  

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1. Same tier 3 topics + same sponsor [1], 3. Any topic + same sponsor [1], 2. Same tags + same sponsor [1], 3. Same sponsor [1],

  • Content Type

  • Expert Insights
  • Sponsor

  • Bio-techne
  • Topic(s)

  • Cell Biology
  • Chemical Biology
  • Life Science
  • Protein Science
  • Tagged With

  • Autophagy-lysosomal Degradation
  • Chemical Biology Tools
  • Clinical Trials
  • Double-membrane Vesicles
  • Lysosome
  • Pharmaceutical Industry
  • Proteasome
  • Protein Degradation
  • Protein Homeostasis
  • Proteolysis Targeting Chimeras (PROTACs)
  • Small-molecule Protein Degraders
  • Targeted Protein Degradation (TPD)
  • Ubiquitin-proteasome System (UPS)

TOPICS

  • Analytical Science
    • Equipment & Lab Automation
      • Balances
      • Detectors
      • Hardware
      • LIMS & ELN
      • Quality assurance
      • Robotics
    • Food Science
      • Liquid Chromatography
      • Mass Spectrometry
      • Quality assurance
    • Materials Science
      • Additive Manufacturing
      • Battery research
      • Industrial Chemistry 
      • UV Spectroscopy
      • X-Ray Analysis
    • Microscopy
      • Electron & Ion Microscopy
      • Image Processing
      • Imaging
      • Light Microscopy
      • Raman Spectroscopy
      • Scanning Probe Microscopy
    • Separation Science
      • Gas Chromatography
      • Liquid Chromatography
      • Mass Spectrometry
      • Sample Preparation
    • Spectrometry
      • Mass Spectrometry
    • Spectroscopy
      • Imaging
      • UV Spectroscopy
      • X-Ray Analysis
      • X-Ray Fluorescence
  • Life Science
    • Bioanalysis
      • Assays
      • Bioprocessing
    • Biochemistry & Biopharma
      • Industrial Chemistry 
    • Cancer
    • Cell & Gene Therapy
    • Cell Biology
    • Chemical Biology
    • Cytometry & Flow Cytometry
    • Environmental Science
      • Quality assurance
    • Essential Laboratory Techniques
      • Sample Preparation
    • Food Science
    • Genetics
    • Health
    • Immunology
    • Lipidomics
    • Microbiology
    • Microscopy
    • Model Organisms
    • Molecular Biology
    • Nanoscience & Nanotechnology
    • Neuroscience
    • Omics
      • Genomics
      • Proteomics
    • Pharmacology
    • Protein Science
    • Spatial Biology
    • Stem Cell Biology
    • Toxicology
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