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This Expert Insights eBook provides researchers with cutting-edge advancements in analytical techniques for therapeutics. By integrating multiple methods, scientists can achieve enhanced precision in structural elucidation, differentiation of complex molecules, and characterization of novel therapeutics. These insights are designed to empower researchers to improve the accuracy and efficiency of therapeutic analysis, ensuring drug quality and safety.
What you will learn about:
- Advanced workflows for metabolite identification and impurity quantification using innovative systems.
- The advantages of electron-activated dissociation (EAD) over collision-induced dissociation (CID) for metabolite identification
- The role of capillary electrophoresis sodium dodecyl sulfate (CE-SDS) in identifying glycosylated heavy chain heterogeneity in monoclonal antibodies.
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Advancements in analytical techniques are transforming drug development and biopharmaceutical analysis. This collection explores how methods like mass spectroscopy (MS) and capillary electrophoresis (CE) are improving precision in therapeutic characterization. By integrating these techniques, researchers can ensure drug safety, efficacy, and quality while addressing critical challenges in the pharma and biotech industries.
Articles contained in the collection:
- Yao, M. et al. (2024). Advancing structural elucidation of conjugation drug metabolites in metabolite profiling with novel electron-activated dissociation. Rapid Communications in Mass Spectrometry. https://doi.org/10.1002/rcm.9890.
- Yang, J. et al. (2024). Reference-free thio-succinimide isomerization characterization by electron-activated dissociation. Rapid Communications in Mass Spectrometry. https://doi.org/10.1002/rcm.9910.
- Li, M. et al. (2024). Using capillary electrophoresis sodium dodecyl sulfate (CE-SDS) and liquid chromatograph mass spectrometry (LC–MS) to identify glycosylated heavy chain heterogeneity in the anti-VEGFR-2 monoclonal antibody. Electrophoresis. https://doi.org/10.1002/elps.202300258.
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