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This Infographic provides researchers with comprehensive information on the 2025 Nobel Prize-winning discoveries in regulatory T cell biology, allowing you to understand how these groundbreaking findings are transforming immunology research and advancing therapeutic development across multiple disease areas.
What you will learn about:
- The 2025 Nobel Prize discoveries by Brunkow, Ramsdell, and Sakaguchi concerning peripheral immune tolerance and regulatory T cells (Tregs)
- How Tregs maintain immune balance and prevent autoimmune diseases through specialized mechanisms
- The critical role of flow cytometry technology in enabling Treg discovery and characterization
- Advanced spectral flow cytometry platforms that reveal unprecedented cellular detail with 40-78 parameter analysis
- Clinical applications spanning cancer immunotherapy, autoimmune diseases, organ transplantation, and cellular therapies
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More Information
The 2025 Nobel Prize in Physiology or Medicine was awarded to Mary E. Brunkow, Frederick J. Ramsdell, and Shimon Sakaguchi for their discoveries concerning peripheral immune tolerance and regulatory T cells (Tregs). These specialized immune cells prevent the body from attacking its own tissues and are essential for preventing autoimmune diseases. The laureates’ work launched the field of peripheral tolerance, spurring development of medical treatments across cancer immunotherapy, autoimmune diseases, organ transplantation, and cellular therapies. Flow cytometry technology was instrumental in enabling these discoveries—from the first commercial FACS instruments in 1974 to today’s advanced spectral platforms analyzing 40-78 parameters simultaneously. This infographic traces the discovery journey from identifying CD4+CD25+ regulatory T cells in 1995, through the discovery of Foxp3 as the master regulator gene in 2001, to current applications in CAR-Treg engineering, low-dose IL-2 therapy, and precision medicine approaches that promise to transform treatment of diseases ranging from type 1 diabetes to cancer.
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