Article Collection: Exosome Production, Isolation and Applications: From Cancer Research to Therapeutic Targets
Extracellular vesicles (EVs), including exosomes , are small, membrane-bound particles that play a critical role in intercellular communication, including in cancer. Here we explore their potential in novel small EV production modulators, EV isolation from plants and purification, engineered exosomes in tumor immunology, and EV bioprocessing. With the crucial role of exosomes in cancer diagnosis and treatment, their isolation remains a crucial area of research for developing diagnostic tools and therapies.
This article collection provides a thorough overview of innovative methods for isolating, identifying, and purifying exosomes. The collection emphasizes the critical role of production and isolation techniques in developing new diagnostic tools and therapies for diverse diseases. Our goal is to showcase these benefits to enable researchers to fully explore their potential.
What you will learn:
- Exosome isolation techniques
- Advances in biomarkers for cancer diagnosis/prognosis
- Engineered exosomes for immunotherapy
- Production of exosomes using bioprocess equipment and purification from plants
Articles contained in the collection:
Tang, Z., Li, D., Hou, S., & Zhu, X. (2020). The cancer exosomes: Clinical implications, applications and challenges. Int J Cancer
Alptekin, A., Parvin, M., Chowdhury, H. I., Rashid, M. H., & Arbab, A. S. (2022). Engineered exosomes for studies in tumor immunology. Immunol Rev
Yamamoto, A., Takahashi, Y., Inuki, S., Nakagawa, S., Nakao, K., Ohno, H., Doi, M., & Takakura, Y. (2022). The identification of novel small extracellular vesicle (sEV) production modulators using luciferase-based sEV quantification method. J Ex Bio
Wang, X., Qian, T., Bao, S., Zhao, H., Chen, H., Xing, Z., Li, Y., Zhang, M., Meng, X., Wang, C., Wang, J., Gao, H., Liu, J., Zhou, M., & Wang, X. (2021). Circulating exosomal miR-363-5p inhibits lymph node metastasis by downregulating PDGFB and serves as a potential noninvasive biomarker for breast cancer. Mol Oncol.
Costa, M. H. G., Costa, M. S., Painho, B., Sousa, C. D., Carrondo, I., Oltra, E., Pelacho, B., Prosper, F., Isidro, I., Alves, P., & Serra, M. (2023). Enhanced bioprocess control to advance the manufacture of mesenchymal stromal cell-derived extracellular vesicles in stirred-tank bioreactors. Biotechnol Bioeng.
Huang, Y., Wang, S., Cai, Q., & Jin, H. (2021). Effective methods for isolation and purification of extracellular vesicles from plants. J. Integr. Plant Biol.
Ditte, Z., Silbern, I., Ditte, P., Urlaub, H., & Eichele, G. (2022). Extracellular vesicles derived from the choroid plexus trigger the differentiation of neural stem cells. J. Extracell. Vesicles.
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