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This Expert Insights eBook hopes to provide scientists with more information on in vitro transcription and mRNA therapeutics, allowing you to further your research in this field.
What you will learn about:
- Targeted gene therapy applications.
- CRISPR/Cas9 delivery for genome editing.
- Advancements in mRNA stabilization and immunogenicity.
More Information
The convergence of lipid nanoparticle (LNP) technology with in vitro transcription (IVT) represents a significant advancement in therapeutic innovation, particularly in the fields of mRNA therapy or CRISPR/Cas9 genome editing. LNPs serve as a protective and efficient delivery system, overcoming the natural barriers that have traditionally limited the therapeutic application of mRNA, such as its susceptibility to enzymatic degradation and poor cellular uptake. The design and optimization of these nanoparticles are critical to the mRNA’s effectiveness, influencing the stability and delivery of mRNA and the specificity of targeting different cell types and tissues.
Articles contained in the collection:
[2] Ma, T., et al. (2023). Intracellular Delivery of mRNA for Cell‐Selective CRISPR/Cas9 Genome Editing using Lipid Nanoparticles. ChemBioChem. DOI: 10.1002/cbic.202200801.
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