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This detailed one-pager is a sneak peek of the Infographic available this Autumn. The infographic offers scientists detailed methodologies for addressing stability challenges in protein therapeutics. Learn about advanced analytical techniques and their practical applications in improving drug development.
What you will learn about:
- Understanding the impact of charge variant heterogeneity on protein stability
- Employing icIEF-UV/MS workflows for detailed analysis of molecular structures
- Identifying chemical modifications such as trisulfide bonds and free thiol groups
- Strategies for optimizing therapeutic candidate selection and development
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More Information
Stability challenges, such as charge variant heterogeneity, can hinder drug development in protein therapeutics. This digest details how analytical techniques like icIEF-UV/MS workflows help identify and address these issues at the molecular level. By linking pI shifts to intact mass changes, researchers can assess protein structural integrity, enabling early intervention and optimizing the development pipeline. Case studies and expert insights demonstrate the transformative impact of these methodologies on biopharmaceutical research.
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